If inhaled If breathed in, move person into fresh air. Environmental: Maleic anhydride's fate in soil is unknown. 1272/2008, Regulation (EC) No.1907/2006 Maleic Anhydride, rev 2 7/2012 Page 2 Basis for Classification This substance is classified based on Directive 1272/2008/EC and its amendments (CLP Regulation,GHS) MALEIC ANHYDRIDE (108-31-6) Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Causes redness and double vision, and "halo" vision. exposure may cause allergic respiratory reaction (asthma). Combustible Solid, but may be difficult to ignite. Memorandum. Chem., 1979, 179, C19], and is considered an excellent dieneophile for Diels-Alder reactions [Felthouse, Timothy R. et al. Product name : Maleic anhydride Product Number : 63200 Brand : Sigma-Aldrich Index-No. Colorless needles, white lumps, or pellets with an irritating, choking odor. CDC twenty four seven. Chronic: Maleic anhydride has several uses, almost all of them related to the synthesis of other chemicals as fumaric and tartaric acids, certain agricultural chemicals (i.e., maleic hydrazide, malathion), lubricants, surface active agents, resins in different products, dye intermediates, pharmaceuticals, and more. Safety Data Sheet (Maleic Anhydride) DATE PREPARED: 9/3/2015 Page 7 of 9 OSHA: No component of this product, present at levels greater than or equal to 0.1%, is identified as a carcinogen or potential carcinogen by OSHA. Maleic Anhydride Flinn Scientific, Inc. P.O. Reproductive Toxicity: No data available Reproductive toxicity - Rat - Oral FIRST AID MEASURES General advice Consult a physician. P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor. ... Maleic anhydride is transported also as hot liquid (70°C); contact of the skin should be avoided. Index -No. Maleic acid 110-16-7 >95 4. Interagency Collaborative Group on Environmental Carcinogens. Pesticide properties for Maleic hydrazide, including approvals, environmental fate, eco-toxicity and human health issues National Cancer Institute, June 17, 1974. Maleic anhydride is a colorless to white solid that forms orthorhombic crystals and decomposes in water. Product Identification Synonyms: cis-Butenedioic anhydride; 2,5-furandione; toxilic anhydride CAS No. Wash out mouth with water. Product name : Maleic Anhydride CAS-No. : 607-096-00-9 CAS-No. Safety Statements :26-36/37/39 (2) Conversion Factors: Causes respiratory Chemical safety data sheet sd-88: properties and essential information for safe handling and use of maleic anhydride. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Click here for information on selection of N, R, or P filters.Any appropriate escape-type, self-contained breathing apparatus, Important additional information about respirator selection, cis-Butenedioic anhydride, 2,5-Furanedione, Maleic acid anhydride, Toxilic anhydride. Exposure to maleic anhydride may occur from accidental releases to the environment or in workplaces where it is produced or used. Causes severe eye and skin irritation with possible Harmful if swallowed. : 108-31-6 Molecular Weight: 98.06 Chemical Formula: C4H2O3 Company: ADDTEK CHEMICAL SHANGHAI CO LTD TEL: +86 21 63352916 FAX: +86 21 51010033EXT8839 NCI [1974]. The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. Causes skin burns. burns. Show this safety data sheet to the doctor in attendance. Maleic anhydride released into water will hydrolyze rapidly (half-life 0.37 min) to maleic acid. Maleic anhydride undergoes a potentially explosive exothermic Diels-Alder reaction with 1-methylsilacyclopenta-2,4-diene at 150C [Barton, T. J., J. Organomet. Prolonged or repeated skin contact may cause dermatitis. Histological examination revealed nephrosis which increased in severity with the dose above 100 mg/kg. (5,8) The vapor pressure for maleic anhydride is 0.1 to 0.2 mm Hg at 25 °C. May cause skin sensitization, an allergic Substance Any concentration shown as a range is to protect confidentiality or is due to batch variation. Corrosive. none Water, Foam, Alcohol resistant foam, ABC-powder Water jet Nitrogen oxides (NOx), Carbon monoxide (CO), Carbon dioxide (CO2) In … EC -No. Causes redness and pain. OSHA Vacated PELs: Acetic anhydride: No OSHA Vacated PELs are listed for this chemical. Evaporate the chloroform in a hood. Ingestion: : 108-31-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratorychemicals, Industrial & for professional use only. Polynt Group produces a great variety of anhydrides, but the most important ones are: Phthalic Anhydrides, Maleic Anhydride, Trimellitic Anhydride MATERIAL SAFETY DATA SHEET MALEIC ANHYDRIDE 1. Do NOT induce vomiting. Product identifier Identification number Name of the substance Maleic anhydride 607-096-00-9 (Index number) Registration number 01-2119472428-31 Synonyms MAN Issue date 07-March-2019 Version number 01 Revision date-Supersedes date-1.2. [Note: Reacts slowly with water (hydrolyzes) to form maleic acid. Stir the mixture for 10 min. First Aid Measures Description of Firstaid Measures General Advice: Consult a physician. Eye: SAFETY DATA SHEET SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Saving Lives, Protecting People, The National Institute for Occupational Safety and Health (NIOSH), National Institute for Occupational Safety and Health, A – NIOSH Potential Occupational Carcinogens, E – OSHA Respirator Requirements for Selected Chemicals, G – 1989 Air Contaminants Update Project: Exposure Limits NOT in Effect, Type C & CE – Definitions for Type C and Type CE Respirators, U.S. Department of Health & Human Services. irritation with nausea, vomiting, and diarrhea. Immediate medical attention is required. Anhydrides. MALEIC ACID page 2 of 6 This Fact Sheet is a summary source of information of all ... (as Maleic Anhydride) exists, use a MSHA/NIOSH approved self-contained breathing apparatus with a full facepiece operated in a … May cause asthmatic attacks due to allergic sensitization of the tract irritation and possible burns. Causes eye burns. (2) Maleic anhydride has an acrid odor, with an odor threshold of 0.32 parts per million (ppm). Maleic anhydride, polymers Safety Profile. SAFETY DATA SHEET (in accordance with Regulation (EU) 2015/830) 108120-Maleic anhydride Version: 3 Revision date: 19/04/2016 Page 2 of 9 Print date: 19/04/2016 -Continued on next page.- P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. reaction, which becomes evident upon re-exposure to this material. Remove victim to fresh Causes chemical burns to the respiratory tract. Product Safety Assessment: Maleic Anhydride Last Revised: August 2015 Page 2 of 3 Potential Human Health Effects Occupational Exposure Potential for occupational exposure to Maleic Anhydride exists during manufacture, at transloading, storage and staging areas, and during mixing and sampling operations in the manufacture of other products. Harmful if swallowed. Box 219, Batavia, IL 60510 (800) 452-1261 Chemtrec Emergency Phone Number: (800) 424-9974 May cause blistering of the skin. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. When heated to decomposition it emits acrid smoke and irritating vapors. Add 0.98 g (0.01 mole) of maleic anhydride to a solution of 1.67 g (0.01 mole) of veratrylamine in 10 mL of chloroform. A poison by intravenous route. respiratory tract. cis-Butenedioic anhydride, 2,5-Furanedione, Maleic acid anhydride, Toxilic anhydride Colorless needles, white lumps, or pellets with an irritating, choking odor. First-aid measures General Advice Show this safety data sheet to the doctor in attendance. Symptoms and effects are not known to date. Moisture sensitive. If not breathing, give artificial respiration. : 108-31-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 1.3 Details of the supplier of the safety data sheet "Maleic Anhydride, Maleic Acid, and Fumaric Acid." Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in … Show this safety data sheet to the doctor in attendance.Move out of dangerous area. Skin: 6. Recrystallize the maleic anhydride from toluene. Hazard classification & labelling Hazard classification and labelling. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Safety Data Sheet 24 hour Emergency Response No. You will be subject to the destination website's privacy policy when you follow the link. Inhalation of high concentrations may cause pulmonary edema. Appearance: white lumps. Target Organs: Lungs, respiratory system, eyes, System RfD (mg/kg-day) Basis PoD Composite UF Confidence; Urinary: 1 x 10 -1: Renal lesions: NOAEL : 1.0 x 10 1 mg/kg-day May cause conjunctivitis. +86-532-8027466 SECTION 1: PRODUCT AND COMPANY IDENTIFICATION ... Acrylic acid maleic anhydride copolymer, aka: 2-propenoic acid, polymer with 2,5, furandion e (cis-butenedioic anhydride) 52255-49-9 : ... Acrylic Acid Maleic … Inhalation: Washington, DC: Manufacturing Chemists Association, p. 1-13. The odour warning when the exposure limit value is exceeded is insufficient. Exposure to high fume concentrations cause photophobia, Acute (short-term) inhalation exposure of humans to maleic anhydride has been observed to cause irritation of the respiratory tract and eye irritation. Maleic anhydride is used in the formulation of resins. Since it biodegrades in sewage treatment plants and hydrolyzes, it's likely that it will degrade in soil. Consult a physician. safety hazards of Maleic Acid to potentially exposed workers. 5. May cause allergic skin and respiratory reaction. Immediate medical attention is required. The anhydride of maleic acid has five atoms in its cyclic molecule, the unsaturated bond undergoes free radical polymerization in the presence of an initiator. Rinse mouth with water (only if the person is conscious). Maleic Anhydride Safety Data Sheet International Diol Company SAFETY DATA SHEET according to Regulation (EC) No. Maleic anhydride CAS -No. Chemical name :maleic anhydride Substance/mixture : Occupational exposure limits, if available, are listed in Section 8. May cause digestive tract Common Name Maleic Anhydride Synonym(s) 2,5Furandione Formula C 4 H 2 O 3 CAS Number 108316 COMPONENT CAS NUMBER CONCENTRATION Maleic Anhydride 108316 ≤ Section 4. 1.3 Details of the supplier of the safety data sheet Company : Central Drug House (P) Ltd 7/28 Vardaan House New Delhi-10002 INDIA Causes gastrointestinal tract burns. Since it biodegrades in sewage treatment plants and hydrolyzes, it's likely that it will degrade in soil. skin. Maleic Anhydride 95 - 100% 108-31-6 Get medical attention immediately. Since it biodegrades in sewage treatment plants and hydrolyzes, it's likely that it will degrade in soil. Move out of dangerous area. Danger! Dissolve the residue in a minimal amount of chloroform. Strong oxidizers, water, alkalis, metals, caustics & amines above 150°F ], inhalation, ingestion, skin and/or eye contact, irritation nose, upper respiratory system; conjunctivitis; photophobia (abnormal visual intolerance to light), double vision; bronchial asthma; dermatitis, Centers for Disease Control and Prevention. Maleic anhydride TWA: 0.01 mg/m 3(Vacated) TWA: 0.25 ppm (Vacated) TWA: 1 mg/m3 TWA: 0.25 ppm TWA: 1 mg/m3 IDLH: 10 mg/m TWA: 0.25 ppm TWA: 1 mg/m3 TWA: 0.01 ppm Legend ACGIH - American Conference of Governmental Industrial Hygienists OSHA - Occupational Safety and … Maleic anhydride in daily doses of 20, 40,100, 250 or 600 mg/kg body weight, fed for 90 days to groups of 15 rats of each sex, caused macroscopic changes in the kidneys: enlargement and pale yellow discoloration. Wear safety goggles or eye protection in combination with breathing protection if powder. 108 -31 -6 203 -571 -6 607 -096 -00 -9 - 4. pain. Risk Statements: 36/37/38 R36/37/38:Irritating to eyes, respiratory system and skin. Repeated Potential Health Effects MCA [1974]. Environmental: Maleic anhydride's fate in soil is unknown. Up to 10 mg/m3: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode£(APF = 50) Any self-contained breathing apparatus with a full facepiece(APF = 50) Any supplied-air respirator with a full facepiece, Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus, Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister having an N100, R100, or P100 filter. A combination of these processes should be important. ) the vapor pressure for maleic anhydride 's fate in soil is unknown 's likely that will. 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