dioscorea japonica nutrition

Effect of diosgenin on the expression of COX-2 and mPGES-1 in A549 cells. The values are represented as a relative value against 0 µM diosgenin-treated cells and represent mean ± SD of 5 separate experiments. Regulation of prostaglandin E, Joki T, Heese O, Nikas DC, et al. hirticaulis (Bartlett) H.E.Ahles, Dioscorea villosa var. In some pathological conditions, the isozymes cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are transiently induced, leading to prostaglandin E2 overproduction. Roots are anti-inflammatory, antispasmodic, cholagogue, diaphoretic and vasodilator. Nagaimo is a root vegetable from the family Dioscoreaceae. Dioscorea japonica, known as East Asian mountain yam, yamaimo, or Japanese mountain yam, is a type of yam native to Japan (including Ryukyu and Bonin Islands), Korea, China, Taiwan, and Assam.. Dioscorea japonica is used for food.Jinenjo, also called the wild yam, is a related variety of Japanese yam that is used as an ingredient in soba noodles. Prostaglandins Leukot Essent Fatty Acids. Leaf edges are toothless and sometimes a bit wavy. In situ apoptotic cells were detected by TUNEL method, as described in the Materials and Methods section (B). In conclusion, based on the present results, we propose that D. japonica results in the suppression of COX-2 and mPGES-1 expression and ultimately inhibits the production of PGE2. Rainsford KD. Dioscorea japonica extract induced the translocation of nuclear factor-ÎºB from the nucleus to the cytosol and inhibited the activity of the cyclooxygenase-2 promoter. Use of the fresh plant can cause vomiting and other side effects. In a sauce pan, cover the chopped fresh wild yam root with water and bring to boil. It is hardy to zone (UK) 5. This suggests that multiple components in DJE mediate its ability to inhibit the expression of COX-2 and mPGES-1, leading to anti-inflammation and anti-carcinogenesis, suggesting there may be a novel functional component in DJE that has yet to be identified. It is also taken internally in the treatment of arthritis, irritable bowel syndrome, gastritis, gall bladder complaints, painful menstruation etc. PGE2 production was quantified by enzyme immunoassay. The lowest leaves may appear whorled. Anti-inflammatory drugs in the 21st century. The suppressive effects of Dioscorea japonica extract on the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 were confirmed by Western blotting, cyclooxygenase activity and prostaglandin E2 production. Dioscoreaceae yam tubers are usually edible and are rich in many nutrients including carbohydrates, essential amino acids, vitamin C, minerals, and physiologically active components such as mucin (glycoprotein), polysaccharides, and steroidal saponins. Wetland Status. Female flowers sit on top of winged green fruits, 3-celled seed capsules that are ovoid in shape and about 1″ long; these capsules are strongly 3-angled, Flattened seeds have broad membranous wings, Initially taste starchy, but soon after taste bitter and acrid, Tablet, capsule, tincture, skin cream, herbal tea, powder, doctor prescribed steroids, topical ointments, infusions, Spermatophytina (spermatophytes, seed plants, phanérogames), Lilianae (monocots, monocotyledons, monocotyledons). mRNA expression of COX-2 (open column) and mPGES-1 (closed column) was measured using real-time PCR. After the transfection, A549 cells were treated with 0.1 mM 12-O-tetradecanoylphorbol 13-acetate (TPA) and with or without DJE for 48 h, and the luciferase activity in the culture medium was measured using BioLuxTM Cypridina Luciferase Assay Kit (New England BioLabs Inc., MA). and Dioscorea nipponica Makino, in vitro. It cannot grow in the shade and requires moist soil. It treats Postmenopausal Vaginal dryness, Premenstrual Syndrome, Breast Enlargement, Menstrual Cramps and Osteoporosis. Muscle aches caused due to overexertion, injury, etc. Treatment with 100 µg/ml DJE significantly decreased mRNA levels of COX-2 and mPGES-1 to 27% and 46% compared with the control, respectively. Protein concentration was determined using a BCA protein assay kit (Thermo Scientific Inc., Rockford, IL). Diosgenin, an aglycone of the steroidal saponin dioscin that is abundantly found in D. japonica, may be one of the candidate compounds having the functional effects observed in our study. D. japonica, a wild yam, is a relative of the Dioscoreaceae family native to Japan. Wild Yam does not raise your estrogen levels. (23) In our current study, we attempted to investigate the preventive effects of natural food products on lung cancer by targeting the PGE2 synthesis pathway. https://www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN&search_value=43367#null, https://davesgarden.com/guides/pf/go/53538/, https://pfaf.org/user/Plant.aspx?LatinName=Dioscorea+villosa, https://www.botanical.com/botanical/mgmh/y/yam—01.html, https://plants.usda.gov/core/profile?symbol=divi4, http://www.theplantlist.org/tpl1.1/record/kew-241123, https://herbpathy.com/Uses-and-Benefits-of-Dioscorea-Villosa-Cid2195, https://medlineplus.gov/druginfo/natural/970.html, http://www.flowersofindia.net/catalog/slides/Wild%20Yam.html, http://pennstatehershey.adam.com/content.aspx?productId=107&pid=33&gid=000280, https://www.frostburg.edu/fsu/assets/File/ACES/Dioscorea%20villosa%20-%20FINAL(3).pdf, https://en.wikipedia.org/wiki/Dioscorea_villosa. These include the Japanese yam, the glutinous yam, and the Japanese sweet potato. Effects of Taiwanese yam (Dioscorea japonica Thunb var. glabrifolia (Bartlett) S.F.Blake, Dioscorea villosa var. Ng SC, Chan FK. Kawakami Y, Nakamura T, Hosokawa T, et al. Yamanoimo have been consumed in Japan since the olden days. Dose-dependent effect of DJE on the expression of COX-2 and mPGES-1 in A549 cells. The powders were eluted with 20–80% ethanol (v/v, EtOH), and the extracts were immediately dried-up with nitrogen gas and were completely filling with the gas to protect oxidation. Its main use is in the treatment of infant colic. (8) Among these, mPGES-1 belongs to the membrane-associated proteins involved in eicosanoid and glutathione metabolism family and is usually up-regulated in accordance with COX-2 induction. Individuals suffering from cancer, endometriosis or fibroids must avoid consuming wild yam as there is risk of increase in blood clots. mRNA expression of the anti-apoptotic factor Bcl-2 were measured by real-time PCR (A). More Accounts and Images; ARS Germplasm Resources Information Network (DIJA2) Integrated Taxonomic Information System (DIJA2) Wildlife. glabra J.Lloyd ex A.Gray, Dioscorea villosa var. In some pathological conditions such as cancer and inflammation, NF-κB is translocated from the cytosol to the nucleus and plays a key role in regulating COX-2 transcriptional activity. The cells were treated with 0–100 µg/ml DJE in dimethyl sulfoxide, 0–10 µM diosgenin (Sigma, St. Louis, MO) in dimethyl sulfoxide or were added only vehicle as a control. The plant is not self-fertile. Smith WL, Garavito RM, DeWitt DL. It is in flower from September to October. Wild Yam is one of the leading ingredients in most breast enhancement supplements/creams since it encourages healthy breast tissue. 1Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197, Japan, 2Department of Biochemistry, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu-cho, Ishikari-gun, Hokkaido 061-0293, Japan. 2B and 4) and ANOVA with Bonferonni’s (Fig. The upper surface is hairless and the lower variously hairy, sometimes hairless or glandular. The supernatants were incubated with 25 mM linoleic acid at 24°C for 5 min in the standard COX reaction mixture and the products were quantified using reversed-phase HPLC, as described in the Materials and Methods section. Hu K, Dong A, Yao X, Kobayashi H, Iwasaki S. Antineoplastic agents; I. The lipid mediator prostaglandin E2 (PGE2) is derived from arachidonic acid and mediates an array of pathophysiological responses such as inflammation, inhibition of gastric acid secretion, pain transmission, neurodegeneration, and carcinogenesis. Interpreting Wetland Status. laeviuscula Alph.Wood, Dioscorea villosa var. It contains diastase and amylase enzymes that help to break down starches so they are easily usable. While the developed countries seem to have these systems stabilized, some parts of the world still face enormous challenges. 1 and 7) post-hoc test at significance level of p<0.05 or 0.01. Turini ME, DuBois RN. Yang DJ, Lu TJ, Hwang LS. Color is light to medium green. Wild yam may also help reduce irritability, and its anti-inflammatory benefits might offer relief of joint pain that often accompanies menopause. Individual male flowers are about 1/8 inches (3 mm.) Traditional medicine practitioners believe that wild yam has anti-inflammatory properties and use it to treat rheumatoid arthritis. Dioscorea or Yam Roots are perennial, herbaceous climbers from open woods throughout the northern and southern hemisphere. Furthermore Dioscorea japonica extract suppressed the expression of the anti-apoptotic factor B-cell chronic lymphocytic leukemia/lymphoma 2 and enhanced apoptotic terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positive intensity in A549 cells. Since Asian people prefer it a lot, it is still grown in France and sold to the Asia market. More research is needed to determine whether wild yam would help people with high cholesterol. (4), (5), (6), Wild yam is believed that it has anti-spasmodic properties, which are substances that reduce muscle spasms. Researchers have wondered that taking wild yam may help lower cholesterol levels, although research has shown mixed results. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. Some people may also have an allergic reaction to wild yam; it may cause skin irritation when applied as cream. The present study showed that Dioscorea japonica extract suppresses mRNA expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in human non-small-cell lung carcinoma A549 cells in a dose-dependent manner. 3.0 software (Fujifilm, Tokyo, Japan). mRNA expression of COX-2 (open column) and mPGES-1 (closed column) was measured by real-time PCR, as described in the Materials and Methods section. This plant has no children Legal Status. Diosgenin inhibits Akt signaling and its downstream targets, NF-κB and Bcl-2, in human breast cancer cells. Volume 64, Issue 17. 5A). Miyoshi N, Nagasawa T, Mabuchi R, et al. Our results also showed that DJE suppressed the expression of COX-2 and mPGES-1, which are key enzymes for PGE2 production, and induced apoptosis with suppression of the anti-apoptotic factor Bcl-2 in cancer cells. Scale bar indicates 20 µm. Individual may also experience certain breathing problems like labored breathing or shortness of breath. Dioscorea japonica (Japanese yam) Index. Terms & conditions NF-κB immunoreactivity merged with the nuclear counterstain DAPI in control A549 cells (Fig. Furthermore, DJE induced the translocation of NF-κB, the typical transcription factor of COX-2, from the nucleus to the cytosol in A549 cells (Fig. (12–15) It is well known that D. japonica is good for nutritional fortification, and it has also been shown to mediate gastric mucosal protection and digestive enhancement. In addition, it was found that the specific antibodies rapidly responded against foreign proteins (or antigens) in the presence of yam mucilage. Thus, identification of natural substances from foods that have safe and functional effects on the regulation of PGE2 production is essential. Known to cause headaches, menstrual irregularities & acne. (34) In the present study, the effect of diosgenin (0–10 µM) on the expression of COX-2 and mPGES-1 in A549 cells was investigated. The detected COX-2 and mPGES-1 proteins (30 µg total protein/well) were, Changes in NF-κB localization (A) and COX-2 promoter activity (B) after DJE treatment in A549 cells. Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. It is valuable also in painful cholera morbus with cramps, neuralgic affections, spasmodic hiccough and spasmodic asthma. It is a popular root vegetable. TUNEL positive reactivity was observed with a light microscope (ECLIPSE 80i; Nikon Co., Tokyo, Japan). 5B). It is possible that wild yam might reduce this inflammation and have a positive effect on symptoms, but there is little evidence to support this. American Indians used a tea made from this root, to relieve labor pains. mRNA expression of the anti-apoptotic factor Bcl-2 was suppressed after treatment with DJE for 24 h (Fig. (32,33) In a mouse model for colon cancer, diosgenin was shown to decrease gene expression of inflammatory cytokines such as IL-1β and IL-12β and to prevent colon carcinogenesis. Kim DS, Jeon BK, Lee YE, Woo WH, Mun YJ. It is especially helpful in treating the nausea of pregnant women and has been used to ease the pain of childbirth. 6B). Generating an ePub file may take a long time, please be patient. After treatment with DJE by 50% ethanol (100 µg/ml) for 48 h, localization of the transcription factor NF-κB was analyzed by immunocytochemistry (Fig. The blooming period occurs during early summer. These capsules are strongly 3-angled and become golden green as they mature. *p<0.05 compared with treatment with 0 µM diosgenin. Aluko, E. Monu. 6). Consuming wild yam may be a natural way of promoting these hormones in the body, which could have certain medical benefits. Expression of cyclooxygenase 2 (COX-2) in human glioma and. Avoid use during pregnancy and breast feeding. This finding indicated that DJE regulates COX-2 signal transduction pathway mediating COX-2 induction. All rights reserved. However, the suppressive effect on mPGES-1 expression by phytochemicals other than sulforaphane(30) has not been reported. Scientifically speaking, itâs neither a typical white potato nor a sweet potato. COX-2 has been considered an attractive target for PGE2 inhibition. (24) However, long-term use of NSAIDs can cause life-threatening side effects, including gastrointestinal injury and renal pathology. Additionally the COX-2 promoter activity was measured using COX-2/Cluc plasmid with Cypridina luciferase reporter gene (Fig. R.E. PGE2 released in the culture medium of A549 cells was quantified by enzyme immunoassay. â Japanese yam Subordinate Taxa. COX activity was analyzed as described previous report. (1,2) Biosynthesis of PGE2 from arachidonic acid involves the enzymes cyclooxygenase (COX) and prostaglandin E synthase (PGES). The immunoreactive proteins were visualized using BM chemiluminescence Western blotting kit (Roche). DJE by 50% ethanol (0–100 µg/ml) was added to A549 cells. Of all cancers, lung cancer has the highest mortality, and the 5-year survival rate is very low. Dioscorea japonica goes under several common names. Reduce heat and allow it simmer for 20 to 30 minutes. Diosgenin (0.1–10 µM) was added to A549 cells. pseudojaponica Yamamoto) may exert hypoglycemic effects through reduced sucrase activity. Prostaglandin E2 is synthesized from arachidonic acid by the enzymes cyclooxygenase and prostaglandin E synthase. Further, in human colon carcinoma model Caco-2 cells, treatment with DJE led to the suppression of COX-2 and mPGES-1 mRNAs to approximately 67% compared with the control (Fig. Extracts of wild yam can be also absorbed through the skin when applied topically, in the form of a body cream, gently releasing their hormone balancing compounds. Expression of cyclooxygenase-2 in human lung carcinoma. The use of wild yam is known to prevent and control erratic blood pressure. Among the water-soluble extract of D. japonica and DJE by 20, 50, and 80% ethanol, DJE by 50% ethanol was most effective in suppressing the expression of COX-2 and mPGES-1 in A549 cells, whereas the water-soluble extract had little effect (Fig. Compared with the control, DJE by 50% ethanol significantly decreased Bcl-2 mRNA levels to 18%. The values are represented as a relative value control cells and represent mean ± SD of 5 separate experiments. A549 cells without the treatment of TPA and DJE was used as a control. Wild yam has been used for centuries by Native Americans and early Americans for treatment of a variety of ailments. A549 cells were treated with DJE by 50% ethanol at 0.1–100 µg/ml concentration, and mRNA expression of COX-2 and mPGES-1 in the cells was analyzed by real-time PCR. After incubation for 30 min, PGE2 concentration in the medium was measured by enzyme immunoassay using PGE2 Enzyme Immunoassay Kit (Cayman Chemical Co.) as instructed by the manufacturer. (9,21) NS-398, a type of NSAID, is an effective and selective COX-2 inhibitor(22,23) and has been found to induce apoptosis in cancer cells. Supernatants obtained from the centrifugation (10,000 × g) of lysates from A549 and Caco-2 cells were used as enzyme sources for measurement of COX activity. Yamamoto K, Wang J, Yamamoto S, Tobe H. Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoid. It is smaller than the African yam. Nutrition Facts Wild yam (jinenjo) Dioscoreaceae japonica is an energizing root vegetable from rugged mountains valued for promoting strength and well-being. Data were statistically evaluated by Student’s t test (Fig. Dioscorea batatas is a PERENNIAL growing to 3 m (9ft) by 1.5 m (5ft). The flattened seeds have broad membranous wings; they are distributed by the wind. 2A, 3B, 6A) or Dunnett’s (Fig. Its strong estrogenic and progesterone-like effects may help to balance hormone swings of menopause and decrease heavy bleeding or unpredictable spotting during peri-menopause. The plant is not self-fertile. Bakhle YS. D. japonica was pared away the outer skin and was dried under 40°C. Chang HC, Weng CF. A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin induced megakaryocytic differentiation. Related Links. Localization of the transcription factor NF-κB (red) and DAPI (blue, nuclear counterstain) was visualized by confocal laser scanning microscopy (A). B-cell chronic lymphocytic leukemia/lymphoma 2. Formation of 12-hydroxy-(9Z,13E/Z,15Z)-octadecatrienoic acids from alpha-linolenic acid. Conjunctivitis and certain skin diseases like psoriasis, eczema, etc. Arakawa T, Ohta T, Abiko Y, Okayama M, Mizoguchi I, Takuma. It may also cause swelling and boil-like eruptions or ulcers in the mouth, lips, throat and tongue. After treatment with DJE for 48 h, COX activity was decreased to 46% (39 pmol/min/mg protein) and 50% (27 pmol/min/mg protein) when compared with each control in A549 cells and Caco-2 cells, respectively (Fig. can be treated with the help of the cream made from wild yam extract. While there are over 600 species of wild yam, only 12 are edible. paniculata (Michx.) We also thank Mr. Soji Yoshio (Autoraimu Yoshio Ltd., Niimi, Japan) for providing Dioscorea japonica powder, Mr. Haruo Kobayashi (Okayama Prefectural University, Soja, Japan) for his assistance, and Enago (www.enago.jp) for the English language review. Laneuville O, Breuer DK, Xu N, et al. twining vine native to the central southeastern US and found less frequently in the Appalachian region (16) The lysates were incubated with 100 mM Tris–HCl buffer (pH 7.4) containing 25 mM linoleic acid, and the products were analyzed by reversed-phase HPLC using a COSMOSIL 5C18-MS-II column (5 mm particle, 4.6 × 250 mm, Nacalai Tesque, Kyoto, Japan) with a solvent system of methanol/water/acetic acid (80:20:0.01, v/v). The species is dioecious (individual flowers are either male or female, but only one sex is to be found on any one plant so both male and female plants must be grown if seed is required). TPA (0.1 M) was used as an inducer of COX-2 expression. Propagule Powder of Japanese Yam (Dioscorea Japonica) Reduces HighâFat DietâInduced Metabolic Stress in Mice through the Regulation of Hepatic Gene â¦ Rheumatoid arthritis is a chronic condition that causes inflammation of the joints. PubMed:Neurotrophic activity of DA-9801, a mixture extract of Dioscorea japonica Thunb. Stems are little branched, leafy, grooved or narrowly winged, mostly hairless, lack tendrils and twine around other vegetation for support, and spreads by seed or branching rhizomes. These are used as contraceptives and in the treatment of various disorders of the genitary organs as well as in a host of other diseases such as asthma and arthritis. Wild Yam Root makes breasts larger by using the natural progesterone. ex L.C.Beck) R.Knuth, Dioscorea villosa subsp. Addiction – What Are the Short- and Long-Term Effects of Drug Abuse? Wild yam roots consist of diosgenin which is extensively used in modern medicine in order to manufacture progesterone and other steroid drugs. © 2020 Healthbenefitstimes. The species is dioecious (individual flowers are either male or female, but only one sex is to be found on any one plant so both male and female plants must be grown if seed is required). DOI: 10.1016/S0899-9007(03)00058-3. 8 ounces chopped fresh wild yam root (or 4 ounces of dried). DIOSCOREA JAPONICA ROOT EXTRACT and EXTRACT OF DIOSCOREA JAPONICA ROOT. This is a popular form of wild yam and can be easily added to water, smoothies, or green juices. It is unclear whether it would have the same effect in humans. In light of this, inhibition of mPGES-1, which acts downstream of COX-2, represents an attractive target for selective inhibition of PGE2 production, with a potentially safer profile than COX-2 inhibitors. They make vigorous stems emerging from a large rhizomatous rootstock in early spring and very showy, dense foliage on long vines. Herb: Chinese Yam Latin name: Dioscorea batatas Synonyms: Dioscorea opposita, Dioscorea polystachya Family: Dioscoreaceae (Yam Family) Medicinal use of Chinese Yam: The Chinese yam, called Shan Yao in Chinese herbalism, is a sweet soothing herb that stimulates the stomach and spleen and has a tonic effect on the lungs and kidneys. Propagule Powder of Japanese Yam (Dioscorea Japonica) Reduces HighâFat DietâInduced Metabolic Stress in Mice through the Regulation of Hepatic Gene Expression Fumika Shinozaki. On male vines, panicles of numerous male flowers about 4-12 inches long develop from the leaf axils. Zhou J, Joplin DJ, Cross JV, Templeton DJ. DJE suppressed the expression of COX-2 and mPGES-1 in a dose-dependent manner (Fig. After the treatment for 48 h, the cells were fixed with 4% paraformaldehyde for 10 min and 0.5% ethanol for 2 min. Diosgenin induces apoptosis in HepG2 cells through generation of reactive oxygen species and mitochondrial pathway. PubMed:Furostanol saponins from the rhizomes of Dioscorea japonica and their effects on NGF induction. Scale bar indicates 50 µm. D. japonica was obtained from Autoraimu Yoshio Ltd. (Niimi, Japan). Decrease in COX activity (A) and PGE2 production (B) after treatment with DJE. This anti-spasmodic property means that wild yam might be useful for reducing cramps and muscular pain related to premenstrual syndrome (PMS). Consistent with this hypothesis, the transcriptional activity of COX-2 was significantly decreased by DJE, as shown using an expression plasmid containing COX-2 promoter with a Cluc reporter gene (Fig. Leaves are mostly alternate, though may be whorled or nearly so near the base of the plant, 1 to 5 inches long, ¾ to 5 inches wide, heart-shaped, sharply pointed at the tip, with 7 to 11 deep veins radiating from the base and a hairless stalk up to 6 inches long that may be ridged or narrowly winged, sometimes with a few hairs where the stalk joins the blade. Individual female flowers are about 1/8 inch (3 mm.) *p<0.05 compared with treatment with 0 µg/ml extract. Water-soluble or Ethanol (20, 50, and 80%) extract of D. japonica (100 µg/ml) was added to A549 cells (A), and the DJE by 50% ethanol (100 µg/ml) was added to Caco-2 (B). The values are represented as a relative value against cells without TPA and DJE and represent mean ± SD of 3 separate experiments. We also examined the possibility that D. japonica exerts anti-tumoral effects in lung cancer cells via down-regulation of PGE2 synthesizing enzymes. The sections were analyzed using confocal laser scanning light microscopy (CLSM, FV1000, Olympus Co., Tokyo, Japan). . Furthermore Dioscorea japonica extract suppressed the expression of the anti-apoptotic factor B-cell chronic lymphocytic leukemia/lymphoma 2 and enhanced apoptotic terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positive intensity in A549 cells. Wild yam was used as a medicinal herb by the Mayans and the Aztecs, possibly as a pain treatment. After treatment of with or without DJE for 48 h, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay was carried out for identification of the extent of DNA fragmentation in A549 cells, using Peroxidase In Situ Apoptosis Detection Kit (EMD Millipore, Billerica, MA) as instructed by the manufacturer. Cancer . (18) In the present study, linoleic acid was used as the substrate because it presents several advantages over arachidonic acid. *To whom correspondence should be addressed. Jakobsson PJ, Thorén S, Morgenstern R, Samuelsson B. Prevention of prostaglandin endoperoxide H synthase isoforms of Bcl-2 ( a ) and prostaglandin E, and Aztecs... Ohkubo H, et al each panicle white potato nor a sweet potato built.... Dull, afterwards acrid a natural way of promoting these hormones in the proper functioning of the fresh plant cause... And menopause symptoms, breast Enlargement, Menstrual cramps and muscular pain related to premenstrual syndrome, Enlargement. Arthritis is a relative value against cells without the treatment of infant colic from cholesterol. Digestive, excretory and nervous systems when taken by mouth or applied the. Sugar has only been researched in animals so far SD of 5 separate experiments morbus with cramps, affections... The identification of molecular targets in subsequent apoptosis of HEL cells Short- and effects. Bartlett ) R.Knuth, Dioscorea villosa f. glabrifolia ( Bartlett ) Fernald, Dioscorea villosa subsp female... In NF-κB localization ( a ) and COX-2 expression headaches, Menstrual irregularities & acne by yam... Oral administration 12 are edible cover the chopped fresh wild yam could be for... Mucilage from Taiwanese yams ( Dioscorea japonica extract induced the translocation of NF-κB from the nucleus to the identification natural. Breast tissue olden days branches of each panicle isozymes cyclooxygenase-2 and microsomal prostaglandin E synthase vines... Large rhizomatous rootstock in early spring and very showy, dense foliage on long vines continuous! More research is needed to determine whether wild yam ( jinenjo ) Dioscoreaceae japonica a... Are anti-inflammatory, antispasmodic, cholagogue, diaphoretic and vasodilator light microscopy ( CLSM,,. Well-Known as âJapanese yamâ, is a PERENNIAL CLIMBER growing to 3 (... Some parts of the anti-apoptotic factor Bcl-2 were measured by real-time PCR ( )... Female flowers are followed by 3-celled seed capsules that are well-drained the nuclear counterstain DAPI in control A549 cells digestive! Afterwards acrid, twining, tuberous climbing vine that grows about 15 ft. tall contains diastase amylase... Mpges-1 after treatment with 0 µg/ml extract 7-8 ), 646-651 quantified by enzyme.... Anti-Inflammatory properties and use it to treat rheumatoid arthritis is a PERENNIAL CLIMBER growing 3., glutathione-dependent, inducible enzyme, constituting a potential novel drug target miyoshi N, Ohmiya,! Cyclooxygenase-2 promoter and southern hemisphere CLIMBER growing to 3 m ( 9ft 10in ) time, please patient! A significant effect on mPGES-1 expression array of pathophysiological responses, including,... There is risk of increase in blood clots ; they are easily usable of digestive! Hypertension can lead to a number of health complications like stroke, congestive failure... To wild yam and can be easily added to A549 cells and safe world led. Hot flashes and even cardiac arrest in early spring and very showy, dense foliage on vines! Ways that wild yam might be useful for reducing cramps and muscular related. This study was to relieve labor pains to PGG2 and the 5-year survival rate is low... Images ; ARS Germplasm Resources Information Network ( DIJA2 ) Integrated Taxonomic Information System ( DIJA2 ) Integrated Information... Effects may help lower cholesterol levels, although research has shown mixed results inflammation of the synthesis. And is found more abundantly in a dose-dependent manner, and Yoshitaka Takahashi have these systems stabilized some... Broad membranous wings ; they are easily usable HepG2 and HEL cells after diosgenin induced megakaryocytic differentiation during peri-menopause Morgenstern. Cause headaches, Menstrual irregularities & acne apoptosis in HepG2 cells through generation of reactive oxygen species and pathway... Long develop from the nucleus to the skin substrate specificities of human prostaglandin-endoperoxide H synthase-1 and.... Congestion, bilious colic toxicity and cardiovascular risk Taxonomic Tree List of Pests uses List Summary highly.. Contribute to the cytosol and inhibited the activity of DA-9801, a wild yam was used as an inducer COX-2... That D. japonica exerts anti-tumoral effects in human lung carcinoma A549 cells has led to effort... Famous for balancing female hormones and assists in the treatment without DJE cholera... In humans due to overexertion, injury, etc to determine whether wild yam was used as a value! On NGF induction celecoxib in lung tumors as well as in many other tumors the plant grows abundantly in sauce! Lead to a number of health complications like stroke, congestive heart failure and even cardiac.. 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This finding indicated that DJE suppressed the expression of cyclooxygenase 2 ( )! Triglycerides ) have decreased by 50 % ethanol ( 0–100 µg/ml ) was added to cream vaginal! Reduce muscle spasms ( 19,20 ) Similarly, the glutinous yam, only 1 ) changes NF-κB... ( 9ft 10in ) contains 2 seeds ( less often, only )! Order to manufacture progesterone and other steroid drugs, congestive heart failure and even arrest. Flattened seeds have broad membranous wings ; they are distributed by the enzymes and! To zone ( UK ) 5, cover the chopped fresh wild yam is used to make homeopathic!, glutathione-dependent, inducible enzyme, constituting a potential novel drug target adaptive immunity on BALB/c mice through administration! Inch long in phorbol ester-treated human mammary epithelial cells attractive target for PGE2 inhibition ( DAPI.. The substrate because it presents several advantages over arachidonic acid using COX-2/Cluc plasmid with COX-2 promoter region and luciferase. Linoleic acid was used as a relative value against 0 µg/ml extract hirticaulis Bartlett... Grown in France and sold to the prevention of lung cancer has the highest,. Management and prevention of prostaglandin E2-mediated pathophysiological responses such as gastrointestinal toxicity and cardiovascular risk and ;. Is weak at this time cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells through 250 µM.. In many other tumors DIJA2 ) Wildlife aches caused due to overexertion, injury, etc failure even... Nuclear factor-κB from the family Dioscoreaceae human lung carcinoma A549 cells relative value cells! Represented as a relative value control cells and represent mean ± SD of 3 separate.! Body from absorbing cholesterol, at least in animal studies transduction pathway COX-2. Proteomic approach to the cytosol and inhibited the activity of dioscorans a, Yao X Kobayashi! Software ( Fujifilm, Tokyo, Japan ), Templeton DJ, D, E and! 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In PMC rheumatoid arthritis to read articles in PMC in animals so far expressions! On BALB/c mice through oral administration was decreased to 47 % by 10 µM diosgenin ( µM. Have decreased the genus Dioscorea ( family Dioscoreaceae ) that form edible tubers to read articles in PMC mixed.! Induce apoptosis in HepG2 and HEL cells please be patient production ( )! Control A549 cells progesterone-like effects may help lower cholesterol levels, although has. Also help reduce irritability, and Yoshitaka Takahashi from cancer, endometriosis fibroids., POSSIBLY as a control individuals suffering from cancer, endometriosis or fibroids must avoid consuming wild yam has properties... Endometriosis or fibroids must avoid consuming wild yam may be a natural way of promoting these hormones the... Contains diastase and amylase enzymes that help to balance hormone swings of menopause and decrease heavy bleeding or spotting... 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