http://theordinary.com/product/rdn-niacinamide-10pct-zinc-1pct-30ml?redir=1, http://theordinary.com/product/rdn-salicylic-acid-2pct-solution-30ml?redir=1. Hughes, M., Williams, G., Baker, P., Green, A. But, there’s a catch. Mao-Qiang, M., Feingold, K., Thornfeldt, C. & Elias, P. (1996). When i googled ethyl ascorbic acid ph level it said 4.0-5.0 so i just dont understand why i cant use ethyl ascorbic acid and buffet together. & Brody, N. (2011). The greasy T-zone had always been there, but the under-skin bumps on my forehead and red, spotty patches were new. However, in certain formulas, the combination of glycolic acid and retinol can be well-tolerated and a complimentary and effective acne treatment. ‘Interaction of vitamins C and E as better cosmeceuticals’. & De Ponti, I. ‘Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color’. Because of this, niacinamide may help counteract the dehydrating effects of retinol and improve the skins tolerance to it. Some research suggests that caffeine enhances the antioxidant effects of green tea polyphenols and that both together may help prevent free radical production and UVB-induced skin cancer [23]. ‘Vitamin E in dermatology’. ‘Pharmacological review on centella asiatica: A potential herbal cure-all’. Ex. Recommended Reading: Can You Use Glycolic Acid and Retinol Together? TULA Clear It Up Acne Clearing + Tone Correcting Gel: A two percent salicylic acid gel, with niacinamide halfway down the ingredients list. Some evidence suggest that this is due to its ability to increase the levels of ceramides, free fatty acids, and cholesterol in the stratum corneum [52]. While some skincare ingredients work against each other or irritate skin when combined, others can enhance each others effects. Keep out of your mouth, nose, and eyes (may burn). Sometimes, more is better! ‘Efficacy and safety of a new superficial chemical peel using alpha-hydroxy acid, vitamin C and oxygen for melasma’. Marczyk, B., Mucha, P., Budzisz, E., Rotsztein, H. (2014). Exfoliation or Masking (Optional) This is a completely optional step (skip to number 3 or 4 if don’t … When used together, start by applying hyaluronic acid then followed by niacinamide. Park, S., Seok, J., Kwak, J. et al. (2008). This is because both vitamin C and glycolic acid are known to boost collagen levels in the skin and it appears that their effects may be additive. ‘Chapter 10: Niacinamide: A topical vitamin with wide-ranging skin appearance benefits’. ‘New insights in photoaging, UVA induced damage and skin types’. Add these two ingredients when cleansing your face and they will flow away directly with the water. If you’ve ever wondered whether you can incorporate niacinamide and acid in one skincare routine, rest assured—you definitely can! For example, a combination of retinaldehyde and glycolic acid demonstrated a good tolerability and significant improvement in acne lesions after 1-3 months of use, The same combination has also demonstrated effectiveness at preventing and healing the post-inflammatory hyperpigmentation (PIH) associated with acne, Research also demonstrates that this formulation can also be used along-side benzyl peroxide and topical antibiotics without causing irritation. Although, resveratrol, alone, performed similarly well to the combination [47]. Sparavigna, A., Tenconi, B. In fact, a large randomized controlled study found that the combination of niacinamide and NAG worked really well at reducing pigmentation. This multi-functional niacinamide serum is a perfect solution for those dealing with both acne and its aftermath. Also to know i can mix Gycolic Acid with Vitamin C. Yeah! Like salacin, salicylic acid is an anti-inflammatory substance with chemical similarities to aspirin. AHAs, such as glycolic and lactic acid, act as chemical exfoliants and help remove dead skin cells and loosen the top layer of skin. Furthermore, niacinamide appears to have an additive effect when combined with NAG. Davis, E. & Callender, V. (2010). Stallings, A. However, even with extremely high doses of oral vitamin C, only a small amount will be available to the skin. Kim, W. (2013). One study found that a topical combination of vitamin C and a centella asiatica extract significantly improved skin suppleness, firmness, and hydration, as well as improving the appearance of wrinkles, after 6 weeks of use, Glycolic acid, an alpha-hydroxy acid that is thought to boost collagen production, was also included in this study. Green tea has demonstrated anti-inflammatory and antioxidant effects in multiple studies. ‘Preliminary open-label clinical evaluation of the soothing and reepithelialisation properties of a novel topical formulation for rosacea’. Hydroxy acids are particularly useful for treating, For example, glycolic acid can significantly improve the resolution of the comedones, papules, and pustules commonly experienced with acne, Retinol also helps to improve acne by increasing the rate of skin cell turnover and renewal which means that dead skin cells are shed quicker. by neutralizing the free radicals that are produced upon exposure to these toxins [14]. Niacinamide offers similar benefits [4], as well as reducing redness and pigmentation and improving skin barrier function [2]. Mukherjee, S., Date, A., Patravale, V. et al. Before all that, you have to know where to start. But, just like retinol, it can be drying to skin. Products That Combine Vitamin C & Glycolic Acid: Another skincare ingredient combination that is often shunned due to its irritation potential is that of retinol and alpha-hydroxy acids (AHAs). Use salicylic acid (psoriasis or seborrheic dermatitis) as ordered by your doctor. The major polyphenol present in green tea is epigallocatechin-3-gallate (EGCG) that has also been shown to have sunscreen properties [21]. Infrared radiation accounts for about 53% and visible light accounts for about 39-44% of total solar radiation [11]. Products That Combine Retinol & Niacinamide: Although the combination of glycolic acid and vitamin C may not be suitable for all skin types, they make a powerful pairing. Jagdeo, J. ‘Topical vitamin C and the skin: mechanisms of action and clinical applications’. Deciem has three skin care brands: Niod, Hylamide and The Ordinary, listed in decreasing order of luxuriousness and price. (2013). In fact, with some formulations it does appear that more is more! This suggests that application of niacinamide is able to prevent the typical irritant effects often experienced upon commencing retinol treatment. For this reason, antioxidants and sunscreens make a perfect pairing and are much more effective when used together. Battie, C., Jitsukawa, S., Bernerd, F., Del Bino, S., Marionnet, C. & Verschoore, M. (2014). This is because both vitamin C and glycolic acid are known to boost collagen levels in the skin and it appears that their effects may be additive. I have long accepted that my skin will never be free from blemishes and oil-overproduction. With thousands of different skincare products available, we’re often spoilt for choice. I always thought that Retinol and AHA could NOT be used together??? ‘Characteristics of the aging skin’. ‘The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer’. Acne Scars vs Acne Marks | A Guide To The Different Causes & Treatment Options. In fact, vitamin C is the best-known stimulator of collagen production [35]. According to Maiman, the combination of azelaic acid, niacinamide and salicylic acid are “generally considered safe for both pregnant and lactating … Vitamin C + Vitamin E + Ferulic Acid = Increased Effect Of Vitamin C By 8x. Can You Use Glycolic Acid and Retinol Together? Bonus tips: Drink lots of water. ‘Applications of hydroxyl acids: classification, mechanisms, and photoactivity’. A number of in vitro and in vivo studies have demonstrated that these lipids, particularly ceramides play a vital role in skin hydration by regulating the amount of water in and out of the skin [26][27]. As you can imagine, the two combined may be quite irritating for skin. All their products are cruelty-free and are not sold in China. Liebel, F., Kaur, S., Ruvolo, E., Kollias, N. & Southall, M. (2012). I am planning on writing a full blogpost on skin care acids, so stay tuned if you want to know more about that. My other concern is can i use more of the same product in a skin care routine. (2002). ‘Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety’. Haywood, R., Wardman, P., Sanders, R. & Linge, C. (2003). (2016). Deciem Responses Regarding Conflicts & The Ordinary Products You Can & Cannot Mix Why can´t I now use Vitamin C derivatives with Niacinamide? Barbara. ‘Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin’. But with so many acids on the market, it can seem overwhelming to remember which to use and for what and which products to buy. Photobiol. Thank you again. Lee, T., Seo, J., Baek, S. & Kim, S. (2014). (2007). Less spots, slightly mire refined pores, over all improved texture. Caffeine has also demonstrated antioxidant and photoprotective effects and offers additional UV radiation and free radical protection when added to sunscreens, As caffeine is present in green tea, both ingredients naturally complement each other’s effects, Some research suggests that caffeine enhances the antioxidant effects of green tea polyphenols and that both together may help prevent free radical production and UVB-induced skin cancer, In addition, the two antioxidants in combination have demonstrated the ability to improve the appearance of acne, Neostrata Restore Redness Neutralizing Serum, The structure and composition of the lipids in the stratum corneum is often referred to as the lipid matrix and creates a barrier function via its mixture of ceramides, cholesterol, and free fatty acids. In addition, free radicals are also produced by other forms of solar radiation, including visible light and infrared radiation. The Importance Of Sunscreen: Scientific Sunscreen Guide Part I. Glycolic acid, alone, boosted collagen production 2-fold (2x), 3-fold (3x) when combined with centella asiatica, and four-fold (4x) when combined with both vitamin C andcentella asiatica [35]. As the stratum corneum is the first to absorb the oxidative stress from free radicals produced by UV radiation, the levels of vitamin E in the skin are often depleted and regular topical application of vitamin E is recommended, Vitamin C and vitamin E are possibly the best example of a skincare power couple as they each enhance the effects of the other. I use the Niacinamide + Zinc first, all over my face (except for my nose, eyes and mouth area!) Resveratrol is the potent antioxidant found in grapes (and red wine!) Niacinamide & Salicylic Acid Niacinamide, a water soluble form of vitamin B3, and salicylic acid, a beta-hydroxy acid, work particularly well when combined together. ‘Human skin-depigmenting effects of resveratryl triglycolate, a hybrid compound of resveratrol and glycolic acid’. & Lim, H. (2008). 2 Common Myths Busted! Photochem. and then the Salicylic Acid directly on spots or spotty areas. Salicylic acid and retinol are medications that can help clear acne. This also means that salicylic acid can access sebaceous glands and reduce sebum production [6]. ‘Antioxidants and the skin: Understanding formulation and efficacy’. If you’re looking for some hormonal breakout warriors, read on! If your makes your skin itchy, don’t use it all. Can you tell i love Vit C? Therefore, it was recommended that in order to achieve optimal results from both ingredients, the two should be used separately. Whenever I feel breakouts coming up, so mostly right before and after my period and whenever I have a bad reaction to a product. ‘Caffeine’s mechanisms of action and its cosmetic use’. The combination of the two completely got rid of my under-skin bumps and any other spots, The Niacinamide helps to balance my skin’s oil-production without completely stripping it, They work really quickly, you get visible results after just one or two uses, They’re so cheap (only around 10 euros each! Together, the duo keeps skin in tact and less apt to become sensitive. ‘Topical retinaldehyde with glycolic acid: study of tolerance and acceptability in association with anti-acne treatments in 1,709 patients’. When added to sunscreen, antioxidants are able to reduce the production of free radicals by up to 78%. With its offer of retinoids, direct acids, oils and more straightforward products, The Ordinary is known to be a very humble and no-nonsense brand. Hydroxy acids are particularly useful for treating acne [1]. She has experience in plastic and reconstructive surgery, dermatology, and aesthetics and has received training in laser treatments. This website is intended for informational and/or educational purposes only. As you can see, niacinamide and salicylic acid offer similar benefits but work in slightly different ways. Specifically, a mix of 0.5% ferulic acid and 1% vitamin E with 15% vitamin C increases the effects of vitamin C eight-fold (8x) [19]. While UV radiation is the most damaging form of solar radiation for the skin, it only accounts for approximately 3-7% of total solar radiation. Available at: Oresajo, C., Pillai, S., Manco, M., Yatskayer, M. & McDaniel D. (2012). The structure and composition of the lipids in the stratum corneum is often referred to as the lipid matrix and creates a barrier function via its mixture of ceramides, cholesterol, and free fatty acids. Great for acne breakouts, salicylic acid shrinks them up, and fast. These two definitely address a certain skin type: the Niacinamide + Zinc is your best friend if you suffer from oily skin, and combined with the the Salicylic Acid it’s perfect to treat blemish- and acne-prone skin. Products That Combine Ceramides & Cholesterol & Fatty Acids: Centella asiatica is a tropical medicinal plant native to Southeast Asia that has antioxidant, anti-aging, and wound healing properties. This makes it a perfect spot treatment while it also improves your skin’s clarity. In addition, AHAs increase the rate of skin cell turnover which helps bring skin pigment to the surface of the skin faster where it can be shed as part of normal epidermal desquamation (skin shedding) [46]. When using hyaluronic acid and retinol, apply retinol first, then hyaluronic acid. Then use The ordinary niacinamide 10% & zinc 1% for oil control you want. Application of one or two of these lipids to dehydrated skin can actually delay the recovery of the skins barrier [29]. This suggests that the combination of zinc oxide and iron oxide in sunscreen is particularly beneficial for individuals with melasma. ‘Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo’. Hello! Post Inflammatory Erythema: 12 Effective Treatment Options. I’m using the salicylic acid cleanser from The Inkey List. These two definitely address a certain skin type: the Niacinamide + Zinc is your best friend if you suffer from oily skin, and combined with the the Salicylic Acid it’s perfect to treat blemish- and acne-prone skin. This product includes niacinamide and vitamin C to help lighten dark spots, retinol to reduce the appearance of fine lines, and salicylic acid to clear blemishes. Should I keep using them at the same time, and if so, in what order? Furthermore, the retinaldehyde and glycolic acid formulation can enhance the effects of these other acne treatments, N-Acetyl Glucosamine (NAG) is an amino sugar and precursor to hyaluronic acid that inhibits tyrosinase glycosylation, thus reducing melanin production, However, NAG can be unstable when used alone, Research suggests that niacinamide can decrease the transfer of melanosomes from melanocytes to keratinocytes by up to 68% and interferes with the cell signalling pathways between keratinocytes and melanocytes. Tanno, O., Ota, Y., Kitamura, N., Katsube, T. & Inoue, S. (2000). For this reason, the combination of vitamin C and centella asiatica may lead to improved anti-oxidant, collagen-boosting, and wound-healing effects. You can find The Ordinary in Belgium on ASOS or the British website Cult Beauty (but they’re very often sold out!). When investigated separately, this combination of resveratrol and glycolic acid inhibited tyrosinase more effectively than glycolic acid alone. ‘Efficiency of opaque photoprotective agents in the visible light range’. (2011). ‘Practical uses of botanicals in skin care’. Gycolic toner, pure L Absorbic Acid powder mix with a snail mucin and a Vit C serum (Andalou) with a Vit C E Ferulic oil?? Read More. Parameshwaraiah, S. & Shivakumar, H. (1998). For this reason, topical application of vitamin C is required to maintain sufficient skin levels of vitamin C [17]. Today, I finally feel as if I have it under control thanks to lots of patience, a dietary turnover and these two products by The Ordinary: the Niacinamide 10% + Zinc 1% and the Salicylic Acid 2% Solution. One study found that, during sun exposure, visible light accounted for 33% of free radical production, while UV radiation accounted for 67%, Some research suggests that iron oxide can increase the overall sun protection offered by zinc oxide sunscreens by absorbing all wavelengths of visible light, This is particularly relevant for individuals with hyperpigmentation and melasma as visible light can increase melanin production, In one study, individuals on a hydroquinone treatment regime were provided with a standard broad-spectrum SPF50 sunscreen or a similar sunscreen that also contained iron oxide and instructed to apply it every day. Although, resveratrol, alone, performed similarly well to the combination, Dr Dennis Gross Alpha Beta Universal Daily Peel, Retinol is a derivative of vitamin A that can increase the rate of, However, initially, retinol can cause irritation and dryness of the skin by damaging the skins barrier and increasing transepidermal water loss (TEWL), Niacinamide is able to stabilise the skins barrier function by reducing the amount of water lost and improving hydration, Some evidence suggest that this is due to its ability to increase the levels of ceramides, free fatty acids, and cholesterol in the stratum corneum. This means you can use niacinamide and vitamin C together without any problem. It contains 2% of salicylic acid that works effectively on my skin. Caffeine has also demonstrated antioxidant and photoprotective effects and offers additional UV radiation and free radical protection when added to sunscreens [22]. I like how my skin looks after using for a few days! When this lipid matrix is depleted, skin can become dehydrated [25] which results in rougher and duller looking skin. Salicylic acid can improve the signs of premature skin aging by increasing collagen levels, improving the quality of elastic fibers, and shrinking pores for a smoother complexion, as well as reducing redness and pigmentation and improving skin barrier function, As salicylic acid is oil-soluble, it easily penetrates pores in order to unclog them by loosening and detaching the skin cells and debris that build up within the hair follicle, This also means that salicylic acid can access sebaceous glands and reduce sebum production, Niacinamide reduces sebum production by decreasing the glyceride and fatty acids of surface sebum which helps to, Enlarged pores are caused by two main factors; increased sebum levels and reduced levels of collagen and elasticity in the skin. Specifically, when iron oxide is combined with zinc oxide, it can reduce the amount of UVA rays able to penetrate the skin to 1.5% [37]. 5 Of The Best Hydrating Products For Acne Prone Skin. Retinol + Niacinamide = Increased Tolerability Of Retinol. What Does pH Balanced Mean? Ezra, if you have oily, acne-prone skin stop using a AHA exfoliator and switch to salicylic acid. Vitamin C is the most abundant antioxidant in the skin and is essential for the production of collagen [16]. Some research suggests that glycolic acid, as well as other AHAs, also inhibit tyrosinase [45]. Research suggests that niacinamide can decrease the transfer of melanosomes from melanocytes to keratinocytes by up to 68% and interferes with the cell signalling pathways between keratinocytes and melanocytes [63]. Usuki, A., Ohashi, A., Sato, H., Ochiai, Y., Ichihashi, M. & Funasaka, Y. & Herman, A. ‘Irradiation of skin with visible light induced reactive oxygen species and matrix degrading enzymes’. Combining niacinimadie’s oil-reducing prowess with salicylic acid’s ability to dissolve excess oil is a great way to help keep pores clear and breakouts at bay. N-Acetyl Glucosamine (NAG) is an amino sugar and precursor to hyaluronic acid that inhibits tyrosinase glycosylation, thus reducing melanin production [61]. Follow all instructions closely. The Ordinary is a British brand owned by Deciem (or “The Abnormal Beauty Company”). In fact, the anti-aging effects of vitamin C are enhanced even further when it is combined with, Timeless Skincare 20% Vitamin C, E, & Ferulic Acid Serum, SeoulCeuticals Day Glow Serum 20% Vitamin C, E, & Ferulic Acid Serum With Hyaluronic Acid. Sincerely. Laura is a skincare addict and sunscreen enthusiast with more than 10 years of experience working in healthcare and over 5 years of experience working as a nurse. (1991). Song, X., Xu, A., Pan, W. et al. While all patients experienced reductions in hyperpigmentation, those who used the iron oxide sunscreen experiences significantly greater improvements, Murad City Skin Age Defense Broad-Spectrum SPF 50 PA++++, Skinceuticals UV Defense Broad-Spectrum SPF50 Physical Fusion Sunscreen, Tizo 3 Tinted Face Mineral SPF40 Sunscreen, Another great skincare ingredient combination for, Resveratrol is the potent antioxidant found in grapes (and red wine!) ‘Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier’. 82, 1123– 1131. ‘Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial’. Frederick, J., Snell, H. & Haywood, E. (1989) ‘Solar ultraviolet radiation at the earth’s surface’. We read a news article that suggests that ingredient X is the next best skincare saviour. For this reason, topical application of vitamin C is required to maintain sufficient skin levels of vitamin C, Vitamin E is the most important lipid-soluble antioxidant in tissue and is particularly abundant in the outermost layer of the skin (the stratum corneum) where it is delivered by sebum. The Ordinary! Let us know in the comments section! Ingredients. In fact, a large randomized controlled study found that the combination of niacinamide and NAG worked really well at reducing pigmentation. Lol. Bissett, D., Oblong, J. Al-Niaimi, F. & Chiang, N. (2017). (2002). Considering the price, it is probably best to save this product just for the dark spots that rea I was so confused. Glycolic acid, alone, boosted collagen production 2-fold (2x), 3-fold (3x) when combined with centella asiatica, and four-fold (4x) when combined with both vitamin C, Centella Asiatica + Vitamin A + Vitamin C + Vitamin E = 3x, Centella Asiatica + Vitamin C + Glycolic Acid = 4x, Zinc oxide is a mineral (physical/inorganic) sunscreen, which means that it protects the skin from UVA and UVB radiation by reflecting and scattering light. Products That Combine Vitamin C & Vitamin E & Ferulic Acid: Another great antioxidant pairing is green tea and caffeine. However, the above research proves that this is not necessarily the case. Tfayli, A., Jamal, D., Vyumvuhore, R., Manfait, M. & Baillet-Guffroy, A. This is because roughly 80-90% of all facial skin aging is caused by sun damage [8]. Ceramides account for about 45-50% of this mixture, cholesterol for approximately 25%, and free fatty acids for around 10-15% [25]. Visible light, especially high energy visible (HEV) light, represents about 39-44% of total solar radiation and enters the skin in the same way that UV radiation does [38]. (2010). The addition of, Like UV radiation, visible light can also lead to the production of free radicals. Herman, A. Chamlin, S., Kao, J., Frieden, I. et al. Glycolic acid, an alpha-hydroxy acid that is thought to boost collagen production, was also included in this study. In one study, individuals on a hydroquinone treatment regime were provided with a standard broad-spectrum SPF50 sunscreen or a similar sunscreen that also contained iron oxide and instructed to apply it every day. In addition, the two antioxidants in combination have demonstrated the ability to improve the appearance of acne [24]. that is known to reduce pigmentation and inflammation and has anti-aging properties [43]. Because of this, niacinamide may help counteract the dehydrating effects of retinol and improve the skins tolerance to it. Thanks so much!! ‘Treatments Improving Skin Barrier Function’. One study found that, during sun exposure, visible light accounted for 33% of free radical production, while UV radiation accounted for 67% [39]. But we’re already using the last skincare ingredient that they recommended and it has become our new holy grail product. Both ingredients target both of these causes and research has found that topical combinations of salicylic acid and niacinamide can significantly reduce surface sebum levels and pore size after 12 weeks of use [2]. Vitamin E returns the favor by increasing the action of vitamin C four-fold (4x), In addition, vitamin C is one of the few examples in life where three is not a crowd. Yes, you can pair both of these ingredients together. Centella Asiatica + Vitamin C + Glycolic Acid = Increased Collagen Production by 4x. Posted 12:27 am by & filed under .-sunscreen With antioxidants like vitamin C and E working in tandem to undo the damage caused by UV rays, you’re probably thinking how it makes Products That Combine N-Acetyl Glucosamine & Niacinamide: We have discussed 12 examples of skincare ingredient combinations where less is not more. Golden, G., Guzek, D., Kennedy, A., McKie, J. They have very specific products for any skin type and any concern, at a very low price rate. Notify me of follow-up comments by email. However, initially, retinol can cause irritation and dryness of the skin by damaging the skins barrier and increasing transepidermal water loss (TEWL) [50]. Similar levels of free radical protection are also offered when antioxidants are used alone, Replenix Antioxidant Sunscreen Moisturizer, Murad City Skin Age Defense Broad Spectrum SPF 50 PA++++, La Roche-Posay Anthelios Melt-In Sunscreen Milk SPF 60, Heliocare 360º Gel Oil-Free SPF 50 Sunscreen, However, even with extremely high doses of oral vitamin C, only a small amount will be available to the skin. Lol. As salicylic acid is oil-soluble, it easily penetrates pores in order to unclog them by loosening and detaching the skin cells and debris that build up within the hair follicle [5]. ‘Stratum corneum lipid phase transitions and water barrier properties’. This means that combining the two can have an additive effect. The same combination has also demonstrated effectiveness at preventing and healing the post-inflammatory hyperpigmentation (PIH) associated with acne [59]. Related Reading: Does Niacinamide Cause Purging? Other research has found that glycolic acid and vitamin C combinations are particularly good at treating stretch marks by increasing epidermal and papillary dermal thickness [55]. (2016). Poli, F., Ribet, V., Lauze, C., Adhoute, H. & Morinet, P. (2005). There’s no third wheel here! (1996). I recently started making my own vitamin b3 toner using 1 tsp niacinamide, 1/2 tsp vegetable glycerine, and about 2oz of witch hazel. Both ingredients target both of these causes and research has found that topical combinations of salicylic acid and niacinamide can significantly reduce surface sebum levels and pore size after 12 weeks of use, InstaNatural Age Defying Skin Clearing Moisturizer, This is because roughly 80-90% of all facial skin aging is caused by sun damage, This skin damage occurs when free radicals produced by UV radiation alter cellular DNA and break down the collagen in the skin, In addition, free radicals are also produced by other forms of solar radiation, including visible light and infrared radiation. TruSkin Vitamin C … Scientific research studies are here to help us out! Ultra-thin texture means the skin will absorb this serum quickly, without leaving an oily cast. To illustrate this more clearly, here are the various ingredients and their combinations, as well as how much each ingredient/combination increased collagen production by: This study is an excellent example of how various skincare ingredients can have additive effects when combined together! They are all skin care lines that focus on clinical formulas. Telang, P. (2013). Kimball, A., Kaczvinsky, J., Li, J., Robinson, L. et al. ‘Inhibitory effects of resveratrol on melanin synthesis in ultraviolet B-induced pigmentation in guinea pig skin’. (2013). Can You Use Vitamin C and Retinol Together? Photobiol. Vitamin C and glycolic acid are also useful for treating hyperpigmentation as both are effective at inhibiting tyrosinase and decreasing melanin production, When used together, vitamin C and glycolic acid demonstrated an ability to significantly improve hyperpigmentation, as well as reduce pore size and improve, Other research has found that glycolic acid and vitamin C combinations are particularly good at treating stretch marks by increasing epidermal and papillary dermal thickness, This further highlights an anti-aging benefit of vitamin C and glycolic acid combinations as epidermal and papillary dermal thicknesses both decrease with age leading skin to become more transparent, Another skincare ingredient combination that is often shunned due to its irritation potential is that of retinol and alpha-hydroxy acids (AHAs). “However, like aspirin, salicylic acid also has anti-inflammatory properties which can calm the skin and minimize irritation.” Many labels for acid-based products display the percentage of acid used (i.e., 2 percent salicylic acid), informing consumers of a product’s supposed strength. Another antioxidant skincare ingredient that promotes wound-healing and boosts collagen production is vitamin C [19]. Here are 12 combinations of skincare ingredients that work better together! ‘Nicotinic acid/niacinamide’. For example, in a study that incubated human skin for 48 hours with centella asiatica, vitamin A, vitamin E, vitamin C, and their combinations, each ingredient, alone, increased the production of collagen two-fold (2x). Hello youthful skin! Because of its ability to reduce inflammation, decongest pores and assist with exfoliation, it is commonly used to treat acne," McBride explains. ‘Effects of Visible Light on the Skin’. However, these ingredients can be found in OTC moisturizers and, when applied to the skin, replenish the substances that the stratum corneum is lacking, thus improving skin hydration, Application of one or two of these lipids to dehydrated skin can actually delay the recovery of the skins barrier, A complete mixture of all three substances needs to be applied in order to repair the skin’s barrier function and, In fact, one study found that a topical cream containing ceramides, cholesterol, and fatty acids improved skin hydration within 30 minutes of application, However, not only do all three substances need to be combined for maximum hydration and barrier repair, but they need to be combined in a specific ratio of between 1:1:1 to 3:1:1 (ceramides: cholesterol: free fatty acids), with ceramide-dominant formulations being more suitable for some skin conditions, Centella asiatica is a tropical medicinal plant native to Southeast Asia that has antioxidant, anti-aging, and wound healing properties. Same as AM but without SPF Niacinamide can help decrease retinol irritation, and on top of that, the added barrier function benefit definitely is a plus! ), especially in relation to the effect, The packaging is really simple and practical, no-nonsense, The formula, as I said, is not ideal. Niacinamide, a water-soluble form of vitamin B3, and salicylic acid, a beta-hydroxy acid, work particularly well when combined together. Laura is currently working in healthcare education and writes for ScienceBecomesHer in her spare time. Its effects are thought to be largely due to various, A number of studies that have investigated the wound-healing benefits of centella asiatica have found that topical application of the extract increases the production of collagen, Another antioxidant skincare ingredient that promotes wound-healing and boosts collagen production is vitamin C. For this reason, the combination of vitamin C and centella asiatica may lead to improved anti-oxidant, collagen-boosting, and wound-healing effects. (2005). Berson, D., Osborne, R., Oblong, J., Hakozaki, T., Jonson, M. & Bissett, D. (2014). Other ingredient combinations to check out: Have you found any skincare ingredient combinations that work particularly well? ‘The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells’. (2006). Research also demonstrates that this formulation can also be used along-side benzyl peroxide and topical antibiotics without causing irritation. Specifically, 4% niacinamide combined with 2% NAG was significantly more effective at reducing pigmentation than a vehicle control formulation [64]. Do not take salicylic acid (psoriasis or seborrheic dermatitis) by mouth. When used together, vitamin C and glycolic acid demonstrated an ability to significantly improve hyperpigmentation, as well as reduce pore size and improve skin texture [54]. ‘An overview of ultraviolet radiation, sunscreens, and photo-induced dermatoses’, Haywood, R. (2006) Relevance of sunscreen application method, visible light and sunlight intensity to free-radical protection: A study of ex vivo human skin. Callender, V., St Surin-Lord, S., Davis, E. et al. While there are a few acid treatments out there that also give you a low dose of niacinamide (like the COSRX AHA and BHA ), I do recommend using separate products if you want to see the best results. This skin damage occurs when free radicals produced by UV radiation alter cellular DNA and break down the collagen in the skin [9][10]. Theyre the miracle tools used to fight acne, wrinkles, age spots, scarring, and uneven skin tone. How To Make Your Face Smooth (According To 20+ Research Studies), 12 Combinations Of Skincare Ingredients That Work Better Together, Vitamin C & Vitamin E (& Bonus Ferulic Acid), Centella Asiatica & Vitamin C (& Bonus Glycolic Acid), A Summary Of The Skincare Ingredients That Work Well Together. Salicylic acid can improve the signs of premature skin aging by increasing collagen levels, improving the quality of elastic fibers, and shrinking pores for a smoother complexion [3]. Alternatively, the new active might have been the tipping point, pushing your skin into a state of irritation. Per those acne-fighting benefits, niacinamide is often paired with salicylic acid, a beta-hydroxy acid that’s a mainstay in acne products, says Dr. Frieling. In fact, it can actually stop the visible signs of skin aging when used correctly [7]. ‘Topical green tea polyphenols and caffeine as a treatment for acne vulgaris’. Keen, M. & Hassan, I. Ceramides + Cholesterol + Free Fatty Acids = Increased Skin Hydration. In fact, the anti-aging effects of vitamin C are enhanced even further when it is combined with both vitamin E and ferulic acid! This suggests that application of niacinamide is able to prevent the typical irritant effects often experienced upon commencing retinol treatment. However, what was not discussed (except in the comments section) was whether or not niacinamide is similarly incompatible with other commonly used acidic compounds such as glycolic and salicylic acid. Katsambas, A. Milstone, L. (2004). & Gajjar, A. If it's all in one product and you're worried, then rest assured it doesn't really have bad horrible side effects (unless ur skin hates niacinamide and breaks out from it) Salicylic Acid - BHA Vitamin E returns the favor by increasing the action of vitamin C four-fold (4x) [19][20]. ‘Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity’. ‘The effect of glycolic acid on the treatment of acne in Asian skin’. In one study, pre-treatment of the skin with niacinamide provided additional barrier protection and made the skin more tolerant of retinoic acid (a prescription strength version of retinol) [50]. Burke, K. (2007). This further highlights an anti-aging benefit of vitamin C and glycolic acid combinations as epidermal and papillary dermal thicknesses both decrease with age leading skin to become more transparent [56]. Farage, M., Miller, K., Elsner, P. & Maibach, H. (2008). Using niacinamide and salicylic acid together. I would however not use them when my skin is dehydrated or sensitive, especially not the direct acid. ‘The extracellular matrix of stratum corneum: role of lipids in normal and pathological function’. ‘Post inflammatory hyperpigmentation: etiologic and therapeutic considerations’. Still, if both ur niacinamide and Vit C (LAA) are in 2 different products, then just separate the order and use one in AM/PM lah. Blog About Shop Contact Media Kit Disclaimer. These come up especially around my time of the month and whenever I use a wrong product (hello, over-sensitive skin!). It is recommended to use a mild amino acid facial cleanser to clean the face. Just use them at different times. <3 But, that doesn’t mean these two can’t be part of your anti-acne routine, as well. Products That Combine Glycolic Acid & Resveratrol: Retinol is a derivative of vitamin A that can increase the rate of skin cell turnover and renewal, reduce sun damage, boost collagen production, improve the appearance of wrinkles, reduce pigmentation, and increase skin hydration [49].