Dipotassium Phosphate Side Effects. Bloating. Shields-Cutler, R.; Crowley, J.; Hung, C. et al. Phosphorus is an essential mineral found in every cell of the human body. Brunelli, S. and Goldfarb, S. Hypophosphatemia: Clinical Consequences and Management. Although not all of these side effects may occur, if they do occur they may need medical attention. However, certain types of medical conditions can make your body inefficient at removing extra phosphorus from the blood, which can result in a condition called hyperphosphatemia. Products typically provide 10% or less of the DV for phosphorus, but … He operates a private practice in Santa Monica, California. Injections are generally indicated when the blood phosphorus level drops below .4 millimoles per liter (mmol/L). Hypophosphatemia may also be caused by the overuse of diuretics (water pills) or phosphate-lowering drugs used during kidney dialysis. Read our, Medically reviewed by Arno Kroner, DAOM, LAc, Medically reviewed by Douglas A. Nelson, MD, Medically reviewed by Richard N. Fogoros, MD, Medically reviewed by Ana Maria Kausel, MD, Medically reviewed by Jonathan B. Jassey, DO, Medically reviewed by Jonathan Cluett, MD, Verywell Health uses cookies to provide you with a great user experience. DOI: 10.1186/s12937-015-0017-0. Along with its needed effects, a medicine may cause some unwanted effects. It is always best to store the supplements in their original light-resistant container in a cool, dry room. Calcium phosphate — which you find as tricalcium phosphate in supplements — contains close to 39 percent elemental calcium. Supplements can help you meet your daily needs if your diet isn't quite cutting it. This drug may be used in people who cannot get enough phosphorus from their diets. Phosphate supplements are sometimes used to make the urine more acidic. In addition, phosphorus additives are used in many soft drinks and packaged foods. Nutrients. ... Pu-erh Tea: Benefits, Dosage, Side Effects… Applies to calcium phosphate, tribasic: oral tablet. Advertising revenue supports our not-for-profit mission. It is also believed to enhance athletic performance and strength, although there is little clinical evidence to support this claim. (1997) Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. 2007;18(7):1999-2003; DOI: 10.1681/ASN.2007020143. All rights reserved. This is not a complete list of side effects and others may occur. It is also water-soluble, meaning the body releases it in urine. People almost never suffer from too much Vitamin B6 from food, but they can get too much of it in supplement form if it’s taken for too long . Although not all of these side effects may occur, if they do occur they may need medical attention. This content does not have an English version. Phosphate is also included in many multivitamin/mineral supplements as well as co-formulated supplements designed specifically for bone health. Phosphorus works with calcium to help build healthy bone and teeth. Gastrointestinal. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Phosphate supplements may help reverse this risk by binding with free-circulating calcium and clearing it in the stool. In some cases, separating the drug doses by two to four hours will help overcome the interaction. Phosphorus also regulates how much calcium is in the body and how much is excreted in urine. Nutrition J. Although the main function of phosphorus is to build and maintain bones and teeth, it also plays a major role in the formation of DNA and RNA (the genetic building blocks of the body). J Biol Chem. All rights reserved. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. ISBN-10: 0-309-06350-7ISBN-10: 0-309-06403-1. Phosphorus supports healthy nerve function and the contraction of all your body’s muscles, including the heart. Although not all of these side effects may occur, if they do occur they may need medical attention. Doses tend to range from 50 milligrams (mg) to 100 mg. For U.S.— Recommended Dietary Allowances (RDAs) are the amount of vitamins and minerals needed to provide for adequate nutrition in most healthy persons. Calcium and Phosphate Metabolism, Blood Lipids and Intestinal Sterols in Human Intervention Studies Using Different Sources of Phosphate as Supplements—Pooled Results and Literature Search. Call your doctor for medical advice about side effects. Phosphorus supplements that contain sodium can cause edema in people with heart failure or cirrhosis. The best food sources for phosphorus are meat, dairy, oily fish, and seeds. Beyond the prevention or treatment of phosphorus deficiency, a phosphate supplement may offer specific health benefits, particularly in older adults and people prone to urinary tract infections (UTIs). BENEFITS OF PHOSPHORUS: Phosphorus is the second most plentiful mineral in your body, making up 1% of your body weight. Related Links List Phosphorous Supplement 280 Mg-160 Mg-250 Mg Oral Powder Packet side effects by likelihood and severity. Side Effects of P5P. By using Verywell Health, you accept our, Phytic Acid: Benefits, Side Effects, Dosage, and Interactions, Watch These Nutrients If You Have Diabetes-Related Kidney Disease, What You Need to Know About Calcium and Vitamin D Supplements, X-linked Hypophosphatemia: Symptoms, Causes, Diagnosis, and Treatment, Lactase supplements can help those with lactose intolerance, Food Nutrition Board of the Institute of Medicine, people in intensive care units (up to 33.9 percent), people involved in major trauma, such as a severe burn (75 percent), children zero to six months: 100 milligrams per day (mg/day), adolescents and teens nine to 18 years: 1,250 mg/day, pregnant or lactating women 18 and under: 1,250 mg/day, pregnant or lactating women over 18: 700 mg/day, Pumpkin or squash seeds: 676 mg per 1/4-cup serving, Sunflower sees: 343 mg per 1/4-cup serving, Canned sardines in oil: 363 mg per 2.5-ounce serving, Hard cheese: 302 mg per 1.5-ounce serving, Lentils (cooked): 264 mg per 3/4-cup serving, Canned salmon: 247 mg per 2.5-ounce serving, Canned tuna in water: 104 mg per 2.5-ounce serving. A 2015 study published in the Nutrition Journal proved this wasn't the case. Since the kidneys are less able to clear phosphate from the body, the mineral may accumulate and lead to hyperphosphatemia (excessively high phosphorus levels). Primary information, health benefits, side effects, usage, and other important details Creatinol O-Phosphate (COP) is a synthetic analogue of creatine that was created as a cardioprotective drug, and it appears to be helpful against arrythmia and aid the integrity of cardiac tissue following injections of up to three grams. Lee, A. and Cho, S. Association between phosphorus intake and bone health in the NHANES population. Side effects requiring immediate medical attention. The best dietary sources of phosphorus include dairy products, meat, poultry, fish, and cereal products. Check with your doctor as soon as possible if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Ⓒ 2020 About, Inc. (Dotdash) — All rights reserved. You can also get too much phosphorus, a condition called hyperphosphatemia, if you take too much of the supplement phosphate. Trautvetter, U.; Distcheid, B.; Jahreis, G. et al. Certain drugs may cause decreases in phosphorus levels in the blood, including: Other drugs may cause phosphorus levels to rise excessively, including: If you are being treated with any of these medications, you should not take phosphate supplements without first speaking with your doctor. Doing so prevents excess calcium from being deposited in blood vessels, which can increase the risk of atherosclerosis (hardening of the arteries). Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Unlike certain micronutrients, the body cannot produce phosphorus on its own. Injectable phosphate is sometimes used to treat severe hypophosphatemia. Mayo Clinic does not endorse companies or products. Excess phosphorus can also affect urine acidity and lead to the dislodgement of a previously undiagnosed kidney stone. People with chronic kidney disease may need to avoid phosphate supplements. Phosphate may interact with some pharmaceutical and over-the-counter medications. Never used expired supplements or supplements that are discolored or deteriorating, no matter the "use-by" date. The normal range is .87 to 1.52 mmol/L. Doing so helps ensure that cells and tissues are properly maintained, repaired, and replaced as they age. Human Urinary Composition Controls Antibacterial Activity of Siderocalin. Unless you have a medical condition that requires supplementation, like alcoholism or chronic obstructive pulmonary disease (COPD), you would be better served to eat a healthy, balanced diet rich in macro and trace nutrients. All drugs may cause side effects. Vitamin B6 is a natural substance and the body needs it to produce chemical reactions. But some supplements, like magnesium. 2015;290:15949-60. It is the second most abundant mineral next to calcium, accounting for roughly 1 percent of your total body weight. See our safe care and visitor guidelines, plus trusted coronavirus information. However, many people have no side effects or only have minor side effects. Excessive intake of phosphorus (or phosphate) supplements may worsen conditions such as heart disease, pancreatitis, rickets, osteomalacia (softening of bones), high blood pressure, and liver and kidney disease. According to the current research, high doses of phosphate increase bone mass density (BMD) and bone mass content (BMC) while decreasing the risk of osteoporosis in adults with adequate calcium intake. Most multiple vitamin-mineral supplements do not contain phosphorus for this reason. DOI: 10.3390/nu10070936. 2018;10(7):936. Along with its needed effects, potassium phosphate may cause some unwanted effects. Kidney stones composed of calcium oxalate develop when the urine pH is less than 6.0 (meaning that it is acidic). However, UTIs are more common in women with hypercalcemia (abnormally high calcium) as the increased urinary calcium promoted bacterial growth. To ensure quality and safety, only buy supplements that have been voluntarily submitted for testing by an independent certifying body like the United States Pharmacopeia (USP), ConsumerLab, of NSF International. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Find everything you need to know about Potassium Phosphate And Sodium Phosphate (PHOS-Nak), including what it is used for, warnings, reviews, side effects… According to a 2015 study in the Journal of Biochemical Chemistry, urine with a high pH (meaning that it is less acidic) exerted stronger antimicrobial effects compared to urine with low pH/high acidity. According to Food Nutrition Board of the Institute of Medicine, the recommended dietary intake (RDI) of phosphorus from all sources varies by age and pregnancy status, as follows: Dosages exceeding 3,000 to 3,500 mg/day are generally considered excessive and may adversely affect the balance of macro and trace minerals in your blood. Don’t take this supplement if you’re pregnant or nursing, and take only the recommended amount to prevent the following adverse side effects: red, itchy, irritated skin from continual skin contact; loss of appetite, nausea or vomiting; other gastrointestinal problems and frequent urination. Phosphate supplements are available in tablet or capsule form under various brand names. Some, however, still suggest that the supplement should be approached with caution, particularly for people with pre … The takeaway Phosphorus is … Outside of severe kidney dysfunction, hyperphosphatemia is extremely rare. Along with its needed effects, a medicine may cause some unwanted effects. Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. Phosphorus is used for Nutritional Deficiencies, Increased Blood Calcium Levels, Hyperparathyroidism etc. JASN. Allergies to phosphate are rare, but it's still important to call your doctor or seek emergency care if you experience rash, hives, shortness of breath, rapid heartbeat, or swelling of the face, throat, or tongue after taking a phosphate supplement. These are minerals that the body needs to function normally. Dicalcium Phosphate Side Effects . ... [OTC]) medicines and herbal or vitamin supplements. Other symp… As a supplement, P-5-P is promoted to deliver greater benefits with fewer side effects, but there’s no clinical evidence to back this up. Phosphate supplements are considered safe if taken as prescribed. Phosphorus isn’t commonly supplemented, even though it’s the second most plentiful mineral in our bodies, after calcium. Beyond this, it may potentially cause: This content does not have an Arabic version. However, too much dicalcium phosphate, or dicalcium phosphate taken in conjunction … Therefore, the quality can vary—sometimes significantly. Dipotassium phosphate is declared “generally recognized as safe (GRAS)” by the U.S. Food and Drug Administration (FDA). This site complies with the HONcode standard for trustworthy health information: verify here. Most people get all the phosphorus they need from diet. Phosphate supplement may contain a large amount of sodium. Moreover, increased phosphate intake was not associated with toxicity. If you notice any other effects, check with your healthcare professional. 2015;14:28. If you have any questions about this, check with your health care professional. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. The excessive intake of phosphate may interfere with the body's ability to use iron, calcium, magnesium, and zinc. These side effects may go away during treatment as your body adjusts to the medicine. For Healthcare Professionals. Though this is not true with all stones. Phosphate supplement side effects. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Portions of this document last updated: Oct. 01, 2020. Dietary supplements are largely unregulated in the United States and are not subject to the rigorous testing and research that pharmaceutical drugs are. Drug information provided by: IBM Micromedex. The daily amount of phosphorus needed is defined in several different ways. These could be signs of potentially life-threatening, whole-body reaction known as anaphylaxis. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Phosphate Supplement (Oral Route, Parenteral Route), FREE book offer – Mayo Clinic Health Letter, decrease in amount of urine or in frequency of urination, numbness, tingling, pain, or weakness in hands or feet, shortness of breath or troubled breathing. Pyridoxal 5 Phosphate Side Effects We can almost never get enough vitamin B6 from food, but we can get too much of it in supplement form if it’s taken for too long a period ( x ). These minerals are converted in the body into calcium phosphate salts that stiffen and strengthen bones. Drug information provided by: IBM Micromedex. Pyridoxal phosphate or P-5-P is the active form of vitamin B6, a crucial nutrient for physical and mental health. Washington, D.C.: National Academies Press (US). Talk with your physician before taking phosphorus supplements if … What are some other side effects of Sodium Phosphates Tablets? By lowering the pH (and increasing the acidity), phosphate may able to prevent kidney stones in high-risk individuals. Excessively high levels of phosphorus in the blood, although rare, can combine with calcium to form deposits in soft tissues, such as muscle. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Belly pain. Phosphate supplements are vulnerable to extreme heat, humidity, and ultraviolet (UV) radiation. A phosphate supplement is typically used to prevent a phosphorus deficiency, a condition considered rare in the United States outside of certain high-risk groups. Thank you, {{form.email}}, for signing up. Although not all of these side effects may occur, if they do occur they may need medical attention. You may report side effects to the FDA at 1-800-FDA-1088. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. High doses can lead to headaches, nausea, dizziness, diarrhea, and vomiting. Dicalcium phosphate is a calcium supplement commonly found in prepared breakfast cereals, in pharmaceuticals as an inert ingredient to bind tablets, and in toothpastes. You may report side effects to Health Canada at 1-866-234-2345. Foods especially rich in phosphorus include: Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Along with its needed effects, a medicine may cause some unwanted effects. According to a study from Harvard Medical School, phosphorus deficiency is most commonly seen in: Low phosphorus can also affect people with certain diseases or medical conditions, including Cushing's disease, hypothyroidism, parathyroid disease, vitamin D deficiency, and malnutrition. Copyright © 2020 IBM Watson Health. Allergies to phosphate are rare, but it's still important to call your doctor or seek emergency care if you experience rash, hives, shortness of breath, rapid heartbeat, or swelling of the face, throat, or tongue after taking a phosphate supplement. However, certain diets and health conditions can cause phosphorus … These could be signs of potentially life-threatening, whole-body reaction known as anaphylaxis. Phosphorus is also considered a macromineral (alongside calcium, sodium, magnesium, potassium, chloride, and sulfur) in that you need more of it than trace minerals like iron and zinc. James Myhre is an American journalist and HIV educator. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Phosphorus is a mineral that’s found in the bones and processed by the kidneys. In addition, individuals who suffer from Addison's disease or disorders of the thyroid, lung and liver may be more likely to accumulate a high concentration of phosphorus in their blood if they take phosphorus supplements. In fact, 85 percent of the phosphorus found in the body resides in … Side Effects Phosphorus is so readily available in the food supply, so deficiency is rare. Due to this, phosphate is rarely taken on its own but rather as part of a multivitamin/mineral supplement. Upset stomach or throwing up. Phosphate injections are only given in a healthcare setting under the direction of a qualified specialist. High doses can lead to headaches, nausea, dizziness, diarrhea, and vomiting. Symptoms may include rash, itching, muscle cramps, spasms, bone or joint pain, or numbness and tingling around the mouth. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). For phosphate supplement: Adults—One or two tablets four times a day. But stay on the safe side and look for supplements made from plants. Arno Kroner, DAOM, LAc, is a board-certified acupuncturist, as well as an herbalist and integrative medicine doctor. Phosphorus is one of 16 essential minerals. calcium or zinc, may cause side effects. Along with its needed effects, a medicine may cause some unwanted effects. That’s because most diets are typically plentiful in phosphorus, and too much can be an issue. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Approximately 85% of Phosphorus is found in your bones and teeth. What are the side effects and safety precautions of taking a phosphorus supplement? It has long been presumed that doing so can help treat certain urinary tract infections or prevent the formation of kidney stones. Phosphorus also plays a key role in metabolism (the conversion of calories and oxygen to energy), muscle contraction, heart rhythm, and the transmission of nerve signals. Side effects from phosphorus intake are rare because healthy kidneys help remove extra phosphate from your body to keep your blood levels in balance. These side effects may go away during treatment as your body adjusts to the medicine. A deficiency of phosphorus is usually accompanied by hypophosphatemia, or low blood phosphate levels, which can affect every organ system of the body and may lead to muscle weakness, bone pain, fractures, seizures, and respiratory failure. You need to obtain it from food and, if needed, a dietary supplement (phosphate is the drug form of phosphorus). Call your doctor for medical advice about side effects. In the past, there was a concern that consuming too much phosphate could throw off this fine-tuned balance, drawing calcium from bone and increasing the risk of osteoporosis (bone mineral loss). DOI: 10.1074/jbc.M115.645812. Recent studies, however, suggest that this may not be the case. Phosphorus supplements might also help with bone restoration and treating excessive levels of calcium in the body due to overactive parathyroid glands. Similarly, kidney stones composed of calcium phosphate tend to develop when the urine pH is over 7.2 (meaning that it is alkaline). Hyperphosphatemia is typically accompanied by low levels of calcium which may result in muscle cramps, muscle spasms, and perioral (by the mouth) numbness or tingling. Side Effects. Side Effects. In others, a dose adjustment or drug substitution may be needed. Where to Find It Phosphorus is highest in protein-rich foods and cereal grains. 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Do occur they may need medical attention [ OTC ] ) medicines and herbal vitamin! } }, for signing up their original light-resistant container in a cool, room. Used to treat severe hypophosphatemia tribasic: Oral tablet is the active form of vitamin B6, a nutrient. You up to date on a wide variety of health topics milligrams ( mg ) to 100.! Risk by binding with free-circulating calcium and clearing it in the bones and teeth in women with (! Likelihood and severity given in a healthcare setting under the direction of a specialist. The takeaway phosphorus is used for Nutritional Deficiencies, increased blood calcium Levels, Hyperparathyroidism.! Deficiency is rare ( US ) Standing Committee on the Scientific Evaluation dietary! Are minerals that the body into calcium phosphorus supplement side effects, tribasic: Oral tablet these are minerals that the body how. 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